Synthesis and Properties of Triphenylgermanium Heteroaromatic Carboxylates and Crystal Structure of Triphenylgermanium 2-Furoate

Ten triphenylgermanium heteroaromatic carboxylates Ph₃GeO₂CR (where R=2-furanyl, 2-furanvinyl, 2-(5-tertbutyl) furanyl, 2-thiophenyl, 2-pyridinyl, 3-pyridinyl, 4-pyridinyl, 3-indolyl, 3-indolylmethyl, 3-indolylpropyl) were synthesized by the reaction of sodium heteroaromatic carboxylates with the triphenylgermanium chloride. All compounds were characterized by elemental analysis, ¹H NMR and MS spectra. The compounds were tested against two human tumour cell lines: MCF-7 and WiDr. The results showed that they had high activities. The crystal structure of triphenylgermanium 2-furoate was determined by X-ray single crystal diffraction. The crystal belongs to monoclinic with space group P2₁/c, a = 1.1545(4), b=0.9934(3), c = 1.6284(5) nm, β= 91.59(5), Z = 4. In this crystal, the structure consists of discrete molecule containing four-coordinate germanium atom in a distored tetrahedron.