Engineering Chiral Catalysts through Asymmetric Activation and Super High Throughput Screening (SHTS)
Koichi Mkami
Department of Applied Chemistry, Faculty of Engineering, Tokyo Institute of Technology, 2–12–1 Ookayama, Meguro-ku, Tokyo 152, Japan
Search for more papers by this authorToshinobu Korenaga
Department of Applied Chemistry, Faculty of Engineering, Tokyo Institute of Technology, 2–12–1 Ookayama, Meguro-ku, Tokyo 152, Japan
Search for more papers by this authorSatoru Matsukawa
Department of Applied Chemistry, Faculty of Engineering, Tokyo Institute of Technology, 2–12–1 Ookayama, Meguro-ku, Tokyo 152, Japan
Search for more papers by this authorKui-Ling Ding
State Key Laboratory of Organometallic Chemistry, Shanghai Institute of Organic Chemistry, Chinese Academy of Sciences, Shanghai 200032, China
Search for more papers by this authorJiang Long
State Key Laboratory of Organometallic Chemistry, Shanghai Institute of Organic Chemistry, Chinese Academy of Sciences, Shanghai 200032, China
Search for more papers by this authorKoichi Mkami
Department of Applied Chemistry, Faculty of Engineering, Tokyo Institute of Technology, 2–12–1 Ookayama, Meguro-ku, Tokyo 152, Japan
Search for more papers by this authorToshinobu Korenaga
Department of Applied Chemistry, Faculty of Engineering, Tokyo Institute of Technology, 2–12–1 Ookayama, Meguro-ku, Tokyo 152, Japan
Search for more papers by this authorSatoru Matsukawa
Department of Applied Chemistry, Faculty of Engineering, Tokyo Institute of Technology, 2–12–1 Ookayama, Meguro-ku, Tokyo 152, Japan
Search for more papers by this authorKui-Ling Ding
State Key Laboratory of Organometallic Chemistry, Shanghai Institute of Organic Chemistry, Chinese Academy of Sciences, Shanghai 200032, China
Search for more papers by this authorJiang Long
State Key Laboratory of Organometallic Chemistry, Shanghai Institute of Organic Chemistry, Chinese Academy of Sciences, Shanghai 200032, China
Search for more papers by this authorAbstract
A conceptually new strategy for asymmetric catalysis, namely asymmetric activation, in which a chiral activator selectively activates one enantiomer of a racemic chiral catalyst, and a highly efficient screening system for finding the most effective catalysts, namely super high throughput screening (SHTS), by which the reaction can be conducted in parallel and the ee% of the product is allowed to determine within minutes, are summarized in the present account. It is reasonable to believe that SHTS technique combined with asymmetric activation or deactivation principle will provide a very powerful methodology for finding the new catalysts and the best catalyst tuning for asymmetric reactions.
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