Article
Full Access
Comparative studies on the mechanism of uridine phosphorolysis
Abstract
We have used quantum mechanical method to study the transition states(TSs) of uridine phosphorolysis reaction. Comparing the four different reaction pathways and the five transition states obtained, we conclude that enzymatic uridine phosphorolysis takes place mainly according to acid-catalyzed Sn2 mechanism. The proposed reaction pathway is consistent with many experimental results.
