Computer-assisted optimization of temperature programming and flow rate in capillary gas Chromatography

A computer-assisted method is presented for simultaneous optimization of three-factor of temperature programming (initial temperature, temperature rising rate and carrier gas flow rate) for the separation of eleven compounds in capillary gas chromatography. The optimization of the separation over the experimental region is based on a special polynomial from fifteen preliminary experiments using the resolution as the selection criterion. Computer scanning technique was used for optimum selection on three dimensions. Excellent agreement was found between the predicted data and the experimental results.