Volume 43, Issue 18
Heterocyclic Compounds

ChemInform Abstract: Synthesis of 2,5-Disubstituted-3-cyanoindoles.

Mark A. Bobko

Mark A. Bobko

Cancer Res., GlaxoSmithKline, Collegeville, PA 19426, USA

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Karen A. Evans

Karen A. Evans

Cancer Res., GlaxoSmithKline, Collegeville, PA 19426, USA

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Arun C. Kaura

Arun C. Kaura

Cancer Res., GlaxoSmithKline, Collegeville, PA 19426, USA

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Leanna E. Shuster

Leanna E. Shuster

Cancer Res., GlaxoSmithKline, Collegeville, PA 19426, USA

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Dai-Shi Su

Dai-Shi Su

Cancer Res., GlaxoSmithKline, Collegeville, PA 19426, USA

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First published: 05 April 2012

Abstract

A three-step sequence including selective iodination and ring closure with KOtBu via a Modified Madelung reaction yields iodo precursors of type (VI), which can be coupled with arylboronic acids.

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