ChemInform Abstract: Nucleophilic α-Arylation and α-Alkylation of Ketones by Polarity Inversion of N-Alkoxyenamines: Entry to the Umpolung Reaction at the α-Carbon Position of Carbonyl Compounds.

The efficient and transition metal free umpolung reaction by polarity inversion at the β-position of N-alkoxyenamines is characterized by mild conditions and simple transformation of ketones such as (I) into α-substituted ketones (IV) without isolation of the intermediate enamine derivatives (II).