ChemInform Abstract: Synthesis of New Anthracycline Derivatives Including Butyric or Retinoic Acid Moiety.
Abstract
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ChemInform Abstract
New antracycline analogues (I) (8 examples), potential anticancer reagents, are synthesized by acylation of the amino group in the glycon of the anthracycline antibiotics daunomycin and doxorubicin as well as the hydroxyl group at C-14 in the aglycon of doxorubicin using butyric and trans-retinoic acid.