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ChemInform Abstract: Identification of a Series of PPARγ/δ Dual Agonists via Solid-Phase Parallel Synthesis.
First published: 22 May 2010
Abstract
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ChemInform Abstract
A general solid-phase synthesis for identification of PPAR ligands is developed. The synthesis of a 480-member library led to the identification of the potent PPAR γ/δ dual agonist (I). (I) shows good plasma exposure in rats and demonstrates antihyperglycemic and antihyperlipidemic efficacy in diabetic rats.
