Preparative Organic Chemistry
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ChemInform Abstract: Influence of Polyamine Architecture on the Transport and Topoisomerase II Inhibitory Properties of Polyamine DNA-Intercalator Conjugates.
First published: 22 May 2010
Abstract
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ChemInform Abstract
Title investigation is presented in connection with studies on scope and limitations of polyamine transporters for drug delivery. Utilized is a series of spermine derivatives prepared by tethering the N4 and N9 positions of spermine to acridine, anthracene or 7-chloroquinoline motifs.
