Volume 33, Issue 8
Preparative Organic Chemistry
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ChemInform Abstract: β-Peptides as Catalysts: Poly-β-leucine as a Catalyst for the Julia—Colonna Asymmetric Epoxidation of Enones.

Paul E. Coffey

Paul E. Coffey

Dep. Chem., Univ. Liverpool, Liverpool L69 7ZD, UK

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Karl-Heinz Drauz

Karl-Heinz Drauz

Dep. Chem., Univ. Liverpool, Liverpool L69 7ZD, UK

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Stanley M. Roberts

Stanley M. Roberts

Dep. Chem., Univ. Liverpool, Liverpool L69 7ZD, UK

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John Skidmore

John Skidmore

Dep. Chem., Univ. Liverpool, Liverpool L69 7ZD, UK

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John A. Smith

John A. Smith

Dep. Chem., Univ. Liverpool, Liverpool L69 7ZD, UK

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First published: 22 May 2010

Abstract

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ChemInform Abstract

Poly-β-leucines are evaluated as catalysts for the Julia—Colonna asymmetric epoxidation of enones. Poly-β3-leucine is found to catalyze the epoxidation of (E)-α,β-enones with significant enantioselectivity (up to 70% e.e.).

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