ChemInform Abstract: Anticancer Properties for 4,4′-Dihydroxybenzophenone-2,4-dinitrophenylhydrazone (A-007)/3,7-Diaminophenothiazin-5-ium Double Salts.
Abstract
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ChemInform Abstract
Anticancer agent A-007 (I) and phenothiazinium salts, e.g. methylene blue or green or toluidine blue, crystallize as stable double salts from ethanolic solution; however, the crystals obtained are not sufficient for X-ray crystallography determination. The new salts show improved in vitro anticancer activities in comparison with A-007 alone. It is anticipated that the double salts will allow A-007 to penetrate into the deep lymphatic/vascular channels of the dermis, which contain metastatic cancer cells, and improve in vivo anticancer activities.
