ChemInform Abstract: Synthesis of 6-(2-Thienyl)purine Nucleoside Derivatives That Form Unnatural Base Pairs with Pyridin-2-one Nucleosides.
Abstract
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ChemInform Abstract
The unnatural nucleosides (III) as well as the amidite (IX) are prepared for DNA synthesis. Base (IV) reduces the interference in the stacking interactions with the neighboring bases in a DNA duplex and improves the efficiency of the enzymatic incorporation of the nucleoside triphosphate of pyridin-2-one opposite the unnatural base. The furanyl derivatives (IIIa) and (IIIc) gradually decomposes under the basic conditions used in DNA synthesis.
