Heterocyclic Compounds
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ChemInform Abstract: Synthesis and Evaluation of Novel Quinolinones as HIV-1 Reverse Transcriptase Inhibitors.
First published: 23 May 2010
Abstract
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ChemInform Abstract
The synthesis of title compounds affords a mixture of diastereoisomers which can be separated. The resulting racemate [e.g.(XII)] shows lower inhibitory activity as efavirenz, but improved activity against single mutations.
