Preparative Organic Chemistry
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ChemInform Abstract: Deprotection of 2-Pyridyl Sulfonyl Group from Pyridine-2-sulfonamides by Magnesium in Methanol.
First published: 23 May 2010
Abstract
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ChemInform Abstract
Pyridine-2-sulfonamides from primary and secondary amines can be desulfonylated by magnesium in methanol under very mild conditions and in excellent yields. Thus, the 2-pyridinesulfonyl moiety is a convenient amine protecting group.
