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ChemInform Abstract: Stereospecific Reduction of Phosphine Oxides to Phosphines by the Use of a Methylation Reagent and Lithium Aluminum Hydride.
First published: 27 May 2010
Abstract
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ChemInform Abstract
Reduction of various phosphine oxides (I), (III), (V) proceeds smoothly by reaction with a methylating reagent followed by LiAlH4. Using this method at low temperatures, optically active phosphine oxides (I) and (III) can be stereospecifically reduced with inversion of the configuration at the phosphorus atom and with excellent enantioselectivity.
