Heterocyclic Compounds
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ChemInform Abstract: Phthalazine PDE4 Inhibitors. Part 2. The Synthesis and Biological Evaluation of 6-Methoxy-1,4-disubstituted Derivatives.
First published: 27 May 2010
Abstract
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ChemInform Abstract
The synthesis and biological evaluation of a novel series of potent phthalazine PDE4 inhibitors (IX) (17 examples) is reported, demonstrating that it is possible to replace the cyclopentyloxy moiety of rolipram with a proper substituent in position 4 of the phthalazine ring.
