Volume 32, Issue 18
Heterocyclic Compounds
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ChemInform Abstract: The Synthesis of Oxazolines Using the Vilsmeier Reagent.

Peter G. M. Wuts

Peter G. M. Wuts

Chem. Proc. Res. Dev., Pharm. Upjohn Inc., Kalamazoo, MI 49001, USA

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Jill M. Northuis

Jill M. Northuis

Chem. Proc. Res. Dev., Pharm. Upjohn Inc., Kalamazoo, MI 49001, USA

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Tricia A. Kwan

Tricia A. Kwan

Chem. Proc. Res. Dev., Pharm. Upjohn Inc., Kalamazoo, MI 49001, USA

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First published: 27 May 2010

Abstract

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ChemInform Abstract

The Vilsmeier reagent is found to be an efficient agent for the conversion of amido alcohols of type (I) into oxazolines. The reaction with Lawesson reagent directly leads to thiazolines like (VI) (no yields given).

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