ChemInform Abstract: Synthesis and Cytotoxic Activity of a Series of Diacetylenic Compounds Related to Falcarindiol.
Abstract
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ChemInform Abstract
Unsymmetrical diacetylenes (VI) and (VII) are synthesized by modification of the Cadiot—Chodkiewicz coupling reaction of alkynyl bromides (IV) with terminal alkynes. Symmetrical diacetylenes (VIII) and (X) are obtained by using the corresponding alkynyl bromides or by using the Zal′kind modification of the Glaser coupling [(IX)→(X)]. The diacetylenes are tested for in vitro cytotoxic activity against human hepatocellular carcinoma and rat hepatoma cell lines. Compounds (VIc) and (VII) are the most active ones, while symmetrical diacetylenes (VIIIb) and (VIIIc) show intermediate cytotoxicities.
