Preparative Organic Chemistry
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ChemInform Abstract: Nucleophilic Displacements of 2-Perfluoroalkyl-1-iodoethanes: Improved Synthesis of Fluorine-Containing Malonic Esters.
First published: 27 May 2010
Abstract
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ChemInform Abstract
Efficient and selective monoalkylation of 2-perfluoroalkyl-1-iodoethanes (I) with malonates [→(III), 6 examples] is achieved using bases such as K2CO3 or NaH in THF. Scope and limitations of this methodology are established.
