ChemInform Abstract: Synthesis of Ionones and Carvone Analogues: Olfactory Properties and Preliminary Toxicity Assays.
Abstract
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ChemInform Abstract
The influence of an aldehyde function in ketones possessing trimethylcyclohexenylalkenone or p-menthone skeletons on the odor is investigated. Thus, the commercially available α- and β-ionones (I) and (V) and carvone (VII) are formylated by the Vilsmeier reagent. Modifying the work-up, compounds (III), (IV), and (VI) are obtained separately with improved yields, while modifying the reaction time of the formylation of carvone (VII) improves the yield of each product. All compounds have peculiar odors which are different from the starting material, with exception of indene (X). Compounds (VIII) and (IX) are the most promising potential perfume ingredients.
