ChemInform Abstract: Synthesis and Serotonin 2 (5-HT2) Receptor Antagonist Activity of 5-Aminoalkyl-Substituted Pyrrolo[3,2-c]azepines and Related Compounds.
Abstract
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ChemInform Abstract
Ongoing studies lead to the synthesis of a novel series of compounds such as (VI) via different approaches. The most interesting substance is the (S)-enantiomer of (VIa), named SUN C5174, obtained from the racemate via diastereomeric salt formation with L-(+)-tartaric acid followed by fractional recrystallization. The (S)-configuration is established by X-ray analysis of the corresponding salt. SUN C5174 is chosen for clinical trials for the treatment of peripheral circulatory diseases. The preparation of the starting materials (I) is described.
