Volume 31, Issue 34
Natural Products
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ChemInform Abstract: Heteroconjugate Addition Strategy for the Synthesis of the (HIJ)K-Ring Fragment of Ciguatoxin.

Tong-Zhu Liu

Tong-Zhu Liu

Lab. Org. Chem., Grad. Sch. Bioagric. Sci., Nagoya Univ., Chikusa, Nagoya 464, Japan

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Bettina Kirschbaum

Bettina Kirschbaum

Lab. Org. Chem., Grad. Sch. Bioagric. Sci., Nagoya Univ., Chikusa, Nagoya 464, Japan

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Minoru Isobe

Minoru Isobe

Lab. Org. Chem., Grad. Sch. Bioagric. Sci., Nagoya Univ., Chikusa, Nagoya 464, Japan

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First published: 03 June 2010

Abstract

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ChemInform Abstract

A combination strategy of heteroconjugate addition of alkynes (II) to the galactal-based olefin (I) and cobalt complex mediated cyclization is described for the synthesis of the ciguatoxin fragment (V).

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