ChemInform Abstract: Total Synthesis of Optically Active m-Phenylene PGl2 Derivative: Beraprost.
Abstract
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ChemInform Abstract
The synthesis of Beraprost as well as its diastereomers [demonstrated for one isomer (XII)] is described. Key steps of the synthesis are the introduction of side chains by Prins reaction, Wittig reaction, and Wadsworth reaction. By variation of the starting cyclopentanobenzofuran [(I) or its enantiomer] as well as variation of the Wadsworth reagent (X), four diastereomers of the title compound are accessible.
