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ChemInform Abstract: Enzymatic Resolution of Thiazole-Containing Vinyl Carbinols. Synthesis of the C12—C21 Fragment of the Epothilones.
First published: 08 June 2010
Abstract
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ChemInform Abstract
The synthesis of two fragments (S)-(I) and (S)-(IV) of the macrolide epothilone A using enzymatic kinetic resolution as key steps is described. The lipase resolution gives highly enantiomerically enriched vinyl carbinols bearing the key C-15 stereocenter.
