ChemInform Abstract: Improved Synthetic Approaches Toward 2′-O-Methyl Adenosine and Guanosine and Their N-Acyl Derivatives.
Abstract
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ChemInform Abstract
Improved approaches to the title compounds by regioselective methylation of chloropurine riboside (I), methylation—acylation—deamination procedure, cf. (VIII)→(XI), and metal-directed methylation, cf. (XII)→(VII), are developed.