Volume 31, Issue 23
Natural Products
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ChemInform Abstract: Improved Synthetic Approaches Toward 2′-O-Methyl Adenosine and Guanosine and Their N-Acyl Derivatives.

Leonid Beigelman

Leonid Beigelman

Dep. Org. Chem., Ribozyme Pharm. Inc., Boulder, CO 80301, USA

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Peter Haeberli

Peter Haeberli

Dep. Org. Chem., Ribozyme Pharm. Inc., Boulder, CO 80301, USA

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David Sweedler

David Sweedler

Dep. Org. Chem., Ribozyme Pharm. Inc., Boulder, CO 80301, USA

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Alexander Karpeisky

Alexander Karpeisky

Dep. Org. Chem., Ribozyme Pharm. Inc., Boulder, CO 80301, USA

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First published: 08 June 2010

Abstract

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ChemInform Abstract

Improved approaches to the title compounds by regioselective methylation of chloropurine riboside (I), methylation—acylation—deamination procedure, cf. (VIII)→(XI), and metal-directed methylation, cf. (XII)→(VII), are developed.

chemical structure image

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