Volume 31, Issue 23
Heterocyclic Compounds
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ChemInform Abstract: A Versatile Method for the Preparation of 2,2-Disubstituted Morpholine Analogues.

Toshiyasu Takemoto

Toshiyasu Takemoto

Med. Chem. Res. Lab., Sankyo Co., Ltd., Shinagawa, Tokyo 140, Japan

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Yukiko Iio

Yukiko Iio

Med. Chem. Res. Lab., Sankyo Co., Ltd., Shinagawa, Tokyo 140, Japan

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Takahide Nishi

Takahide Nishi

Med. Chem. Res. Lab., Sankyo Co., Ltd., Shinagawa, Tokyo 140, Japan

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First published: 08 June 2010

Abstract

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ChemInform Abstract

A novel two-step methodology for the preparation of 2,2-disubstituted morpholine analogues (IV) via iodoetherification is described. The application of this method allows the synthesis of the key intermediate (IVe) of a tachykinin receptor antagonist.

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