Heterocyclic Compounds
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ChemInform Abstract: Synthesis of Optically Pure 1-(2-Pyridinyl)ethylamine and 4-(2-Pyridinyl)-1,3-oxazolin-2-one.
First published: 08 June 2010
Abstract
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ChemInform Abstract
The key step in the synthesis of the optically active title compounds such as (V) and (VII) is the introduction of the azide. Other solvents than DMSO such as DMF, HMPA, acetonitrile, dioxane, ethanol, and THF are not useful for that reaction. The starting materials are obtained via a lipase-mediated reaction [for (IV) no yields given].
