ChemInform Abstract: Enantioselective Allylic Substitution Catalyzed by an Iridium Complex: Remarkable Effects of the Counter Cation.
Abstract
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ChemInform Abstract
Allylic alkylation reactions of (I) and (V), catalyzed by an iridium complex of chiral aryl phosphites, are investigated. Nucleophilic attack anti to the phosphite ligand leads to the predominant formation of (S)-(III) using lithium and/or zinc as the counter cation. Harder anions favor the formation of (R)-(III). The enantiomeric excess of (S)-(III) is remarkably increased when a combination of lithium and zinc is used as counter cation, cf. (V)→(S)-(III).
