ChemInform Abstract: Replacing Tin in Radical Chemistry: N-Ethylpiperidine Hypophosphite in Cyclization Reactions of Aryl Radicals.
Abstract
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ChemInform Abstract
The use of N-ethylpiperidine hypophosphite (EPHP) in radical cyclization reactions shows that the reagent has some advantages over tributyltin hydride. Thus, the cyclization proceeds well and with respectable yields, even when the substrates present terminal alkenes. Furthermore, the phosphorus-centered radicals show higher chemoselectivity over tributyltin radicals (syringe-pump addition of EPHP can improve the yields).
