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ChemInform Abstract: The Effects of Buffers on the Thermodynamics and Kinetics of Binding Between Positively Charged Cyclodextrins and Phosphate Ester Guests.
First published: 08 June 2010
Abstract
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ChemInform Abstract
It is found that structure and concentration of buffers play an important role in controlling both the thermodynamics and kinetics of binding interactions. Negatively charged buffers compete with the aryl phosphate guest for the positively charged binding site of the cyclodextrin, thus lower the effective binding constant. Positively charged buffers do not strongly compete and are thus more conducive to binding.
