Heterocyclic Compounds
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ChemInform Abstract: Cyclic (4S)-Chloromethyl Sulfite and Sulfate Derivatives of (S)-Glycidol as Valuable Synthetic Equivalents of Scalemic Epichlorohydrin.
First published: 08 June 2010
Abstract
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ChemInform Abstract
The interaction of (S)-glycidol (I) with SOCl2 or SO2Cl2 in stoichiometric amounts leads to the formation of cyclic (4S)-chloromethyl sulfite (II) or sulfate (III) with comparable enantiomeric purity. Based on this reaction, a new procedure for the synthesis of the β-adrenoreceptor blocker (S)-propanolol (VII) is developed.
