ChemInform Abstract: An Effective Method for the Preparation of Optically Active Polyoxy 8-Membered Ring Enone Corresponding to the B Ring of Taxol.
Abstract
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ChemInform Abstract
An effective method for the preparation of 8-membered ring enone (XI), a key intermediate in taxol synthesis, starting from D-pantolactone (I) is accomplished. Key steps of the reaction sequence are the diastereoselective hydroxylation of olefin (IV), the diastereoselective aldol reaction of trialkoxyaldehyde (VI) with ketene acetal (VII) and the aldol-type cyclization of oxoaldehyde (IX).
