Heterocyclic Compounds
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ChemInform Abstract: Synthesis of a New Dual Metalloprotease Inhibitor. Part 2. Stereoselective Synthesis of Peptidomimetic [5.7]-Bicyclic Compounds.
First published: 09 June 2010
Abstract
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ChemInform Abstract
Starting from the known optically active ester (I) the title intermediate (V) in the synthesis of the promising drug ER-40133 for hypertension and congestive heart failure is prepared. One major key step is the reduction in the first step in which LiAlH(O-tBu)3 reduces selectively the trans diastereomer of (I) to an aminal which is then further transformed to (IV).
