Volume 31, Issue 12
Isocyclic Compounds
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ChemInform Abstract: Efficient Syntheses of Cyclopropylacetylene, a Crucial Synthetic Intermediate for Efavirenz (DMP-266) (IV).

Shaun E. Schmidt

Shaun E. Schmidt

Dep. Chem., Univ. South Fla., Tampa, FL 33620, USA

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Ralph N. Salvatore

Ralph N. Salvatore

Dep. Chem., Univ. South Fla., Tampa, FL 33620, USA

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Kyung Woon Jung

Kyung Woon Jung

Dep. Chem., Univ. South Fla., Tampa, FL 33620, USA

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Taesoo Kwon

Taesoo Kwon

Dep. Chem., Univ. South Fla., Tampa, FL 33620, USA

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First published: 09 June 2010

Abstract

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ChemInform Abstract

A cost effective and industrially scalable one-pot route for the synthesis of cyclopropylacetylene (III) via dichloride (II) is detailed. The desired acetylene (III) is obtained free from known side products.

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