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ChemInform Abstract: Evaluation of Oligonucleotides Containing Two Novel 2′-O-Methyl Modified Nucleotide Monomers: A 3′-C-Allyl and a 2′-O,3′-C-Linked Bicyclic Derivative.
First published: 10 June 2010
Abstract
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ChemInform Abstract
Modified oligonucleotides, containing the two novel nucleotides (VI) and (VIII), are shown to hybridize with decreased binding affinity towards complementary single stranded DNA and RNA.
