Heterocyclic Compounds
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ChemInform Abstract: Efficient Tin Hydride-Mediated Radical Cyclization of Secondary Amides. Part 1. Synthesis of a Variety of Substituted Pyrrolidinones.
First published: 10 June 2010
Abstract
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ChemInform Abstract
Secondary haloamides are demonstrated to undergo free radical cyclization reactions in boiling toluene. Bulky N-protection groups, established for related cyclizations, are not required. Diastereoselectivity and efficiency of these reactions are found to depend on nature and position of the C-chain substituents.
