Heterocyclic Compounds
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ChemInform Abstract: Stereoselective Synthesis of Non Symmetric Dihydroxyethylene Dipeptide Isosteres via Epoxyalcohols Derived from α-Amino Acids.
First published: 10 June 2010
Abstract
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ChemInform Abstract
A novel approach to dihydroxyethylene isosteres potentially useful for new HIV-protease inhibitors is developed. Key step in the synthesis is a regio- and stereoselective reaction of the epoxyalcohol (I) with diethyl aluminum cyanide (II).
