ChemInform Abstract: A Convenient Synthesis of (E)-4-Alkoxy-2-amino-3-butenoic Acid Derivatives.
Abstract
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ChemInform Abstract
A general approach to the title compounds, including derivatives having substituents at the 2- and/or 3-position, is presented. The regioselective alkoxycarbonylation reaction of isocyanopropenes of type (I) with chlorocarbonates (II) is the key step of this route, followed either by subsequent transformation of the isocyano group into a formylamino group or by alkylation with alkyl halides using HMPA as a co-solvent before hydrolysis of the isocyano group.
