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ChemInform Abstract: Synthesis of New Building Blocks: Towards the Analogues of Peptide Nucleic Acids (PNAs).
First published: 19 June 2010
Abstract
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ChemInform Abstract
A successful preparation of the methyl ester (IV) as building block for solid-phase synthesis to obtain PNA analogues is described. Compound (IV) is prepared by coupling of the PNA thymine monomer (III) with the isothiocyanate (II), derived from (S)-aspartic acid (I) in a number of steps.
