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ChemInform Abstract: A β-Lactone-Based Strategy Applied to the Total Synthesis of (8S,21S,22S,23R)- and (8R,21S,22S,23R)-Okinonellin B.
First published: 20 June 2010
Abstract
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ChemInform Abstract
The key steps in the synthesis of the title compounds (X) are tandem Mukaiyama aldol—lactonization of the aldehyde (IV) and tandem debenzylation—transacylation of the β-lactone (VI). Natural okinonellin B presumably possesses (8R,21R,22R,23S) stereochemistry.
