Heterocyclic Compounds
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ChemInform Abstract: An Efficient and Stereoselective Conversion of Lactones to Substituted Cyclic Ethers.
First published: 20 June 2010
Abstract
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ChemInform Abstract
Cerium(III) chloride assisted addition of Grignard reagents to lactones and following BF3×OEt2 mediated deoxygenation of the resulting hemiketals [cf. (III)] with triethylsilane provides a general route to cyclic ethers. The process is also effective for the diastereoselective formation of cyclic ethers derived from monosubstituted tetrahydrofuranones.
