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ChemInform Abstract: A Convenient Two-Step One-Pot Synthesis of Phosphonamidates.
First published: 23 June 2010
Abstract
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ChemInform Abstract
Phosphoramidates (IV) of glutamic acid, potential inhibitors of glutamyl hydrolases, are prepared by 1H-tetrazole catalyzed reaction of phosphonyl dichloride (I) with alcohols and glutamic acid benzyl ester. Undesired disubstitution of (I) by the alcohols is minimized due to the presence of 1H-tetrazole.
