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ChemInform Abstract: The Design and Synthesis of Orally Active Short Duration Spiroindane Growth Hormone Secretagogues.
First published: 24 June 2010
Abstract
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ChemInform Abstract
Incorporation of a readily metabolized esters into the spiroindane benzylic position provides a series of highly potent secretagogues. Incorporation of an ester or acid into the benzylic position of the spiroindan increases potency. Thus, (II) is ten times more active than (Ib).
