ChemInform Abstract: Synthesis and Receptor Binding Affinity of Conformationally Restricted Retinoic Acid Analogues.
Abstract
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ChemInform Abstract
Efforts to synthesize two conformationally restricted retinoids utilizing a cyclopropyl ring as bioisostere for the C9—C10 double bond are described. The attempted synthesis of the cis-isomer leads mainly to unidentified products and the unexpected epimerization to the trans-derivative (VII). The latter is synthesized independently starting from the cyclopropane (I).
