Volume 29, Issue 1
Natural Products
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ChemInform Abstract: Synthesis of Some Acridone Alkaloids and Related Compounds.

J.-J. CHEN

J.-J. CHEN

Dep. Chem., La Trobe Univ., Bundoora, Melbourne, Victoria 3083, Australia

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L. W. DEADY

L. W. DEADY

Dep. Chem., La Trobe Univ., Bundoora, Melbourne, Victoria 3083, Australia

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M. F. MACKAY

M. F. MACKAY

Dep. Chem., La Trobe Univ., Bundoora, Melbourne, Victoria 3083, Australia

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First published: 24 June 2010

Abstract

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ChemInform Abstract

The previously reported four-step synthesis of acridinediones (I) is extended by an efficient aromatization with Pd—C leading to 1-hydroxyacridones (II). This new method, along with demethylation with HBr [concomitant loss of the ester group in (IIb)], provides a useful route to various methoxy- and hydroxy-substituted acridones.

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