Heterocyclic Compounds
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ChemInform Abstract: N-Acetylchloroacetamide in Synthesis of Functionally Substituted Pyrido[3′,2′:4,5]thieno[3,2-d]pyrimidin-4(3H)-ones.
First published: 24 June 2010
Abstract
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ChemInform Abstract
A new and convenient method for the regioselective synthesis of the title pyridothienopyrimidinones (IV) based on the alkali-mediated reaction of 3-cyanopyridinethiones (I) with N-acetylchloroacetamide (II) is presented. In the case of derivatives (Ia) and (Ib), the intermediate methylthiopyridines (III) can be isolated.
