Volume 29, Issue 1
Heterocyclic Compounds
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ChemInform Abstract: Synthesis and Receptor Binding Studies of Quinolinic Derivatives as Melatonin Receptor Ligands.

P.-K. LI

P.-K. LI

Dep. Med. Chem., Sch. Pharm., Duquesne Univ., Pittsburgh, PA 15282, USA

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G.-H. CHU

G.-H. CHU

Dep. Med. Chem., Sch. Pharm., Duquesne Univ., Pittsburgh, PA 15282, USA

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M. L. GILLEN

M. L. GILLEN

Dep. Med. Chem., Sch. Pharm., Duquesne Univ., Pittsburgh, PA 15282, USA

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P. A. WITT-ENDERBY

P. A. WITT-ENDERBY

Dep. Med. Chem., Sch. Pharm., Duquesne Univ., Pittsburgh, PA 15282, USA

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First published: 24 June 2010

Abstract

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ChemInform Abstract

Ligands containing a neutral moiety within the nucleus, e.g. (VI), display high affinity for melatonin receptors while those analogues containing a permanently charged nucleus, e.g. (VIII), have very low receptor affinity.

chemical structure image

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