ChemInform Abstract: Chemistry of 5-Oxodihydroisoxazoles. Part 17. Acylation of 5-Oxodihydroisoxazoles.
Abstract
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ChemInform Abstract
Acylation of isoxazolones (I) yields N- and O-acylated products (III) and (IV), resp., in ratios strongly depending on the nature of the substituents present at the isoxazolone ring. Aliphatic acid chlorides generally give N-acylated products (III), while aroyl chlorides give significant proportions of O-acylated products (IV), if there is no electron withdrawing substituent at C-4.
