Volume 29, Issue 1
Heterocyclic Compounds
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ChemInform Abstract: Functionalized Pyrrolidinones Derived from (S)-Pyroglutamic Acid by Cycloaddition Reactions.

J. H. BAILEY

J. H. BAILEY

Dyson Perrins Lab., Oxford Cent. Mol. Sci., Oxford Univ., Oxford OX1 3QY, UK

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D. T. CHERRY

D. T. CHERRY

Dyson Perrins Lab., Oxford Cent. Mol. Sci., Oxford Univ., Oxford OX1 3QY, UK

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K. M. CRAPNELL

K. M. CRAPNELL

Dyson Perrins Lab., Oxford Cent. Mol. Sci., Oxford Univ., Oxford OX1 3QY, UK

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M. G. MOLONEY

M. G. MOLONEY

Dyson Perrins Lab., Oxford Cent. Mol. Sci., Oxford Univ., Oxford OX1 3QY, UK

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S. B. SHIM

S. B. SHIM

Dyson Perrins Lab., Oxford Cent. Mol. Sci., Oxford Univ., Oxford OX1 3QY, UK

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M. J. BAMFORD

M. J. BAMFORD

Dyson Perrins Lab., Oxford Cent. Mol. Sci., Oxford Univ., Oxford OX1 3QY, UK

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R. B. LAMONT

R. B. LAMONT

Dyson Perrins Lab., Oxford Cent. Mol. Sci., Oxford Univ., Oxford OX1 3QY, UK

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First published: 24 June 2010

Abstract

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ChemInform Abstract

The lactams (I), derived from (S)-pyroglutamic acid, easily undergo cycloaddition with dienes and 1,3-dipoles. The biologically interesting cycloadducts are formed with excellent regio- and diastereocontrol.

chemical structure image

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