Preparative Organic Chemistry
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ChemInform Abstract: Ester Derived Titanium Enolate Aldol Reaction: Highly Diastereoselective Synthesis of syn- and anti-Aldols.
First published: 24 June 2010
Abstract
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ChemInform Abstract
Titanium enolates derived from esters (I) undergo aldol reactions with the bidentate aldehydes (II) yielding the adducts (III) with high syn-diastereoselectivities. In contrast, reactions of the monodentate isovaleraldehyde (V) proceed with excellent anti-selectivity.
